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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fis1tm1.1Dcc
targeted mutation 1.1, David C Chan
MGI:6755478
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Fis1tm1Dcc/Fis1tm1.1Dcc
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Tg(Stra8-icre)1Reb/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ MGI:6755500


Genotype
MGI:6755500
cn1
Allelic
Composition
Fis1tm1Dcc/Fis1tm1.1Dcc
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Tg(Stra8-icre)1Reb/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fis1tm1.1Dcc mutation (0 available); any Fis1 mutation (47 available)
Fis1tm1Dcc mutation (0 available); any Fis1 mutation (47 available)
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Stra8-icre)1Reb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• no spermatozoa in epididymides
• impaired acrosome development and failure to produce elongated spermatids
• with increased mitochondria content
• 4-fold increase in tubules

cellular
• no spermatozoa in epididymides
• impaired acrosome development and failure to produce elongated spermatids
• with increased mitochondria content
• in round spermatids and giant cells
• in round spermatids and giant cells with aberrant accumulation of autophagic structures
• 4-fold increase in tubules

homeostasis/metabolism
• in round spermatids and giant cells with aberrant accumulation of autophagic structures

endocrine/exocrine glands





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory