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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fis1tm1.1Dcc
targeted mutation 1.1, David C Chan
MGI:6755478
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fis1tm1Dcc/Fis1tm1.1Dcc
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Tg(Stra8-icre)1Reb/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ MGI:6755500


Genotype
MGI:6755500
cn1
Allelic
Composition		 Fis1tm1Dcc/Fis1tm1.1Dcc
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fis1tm1.1Dcc mutation (0 available); any Fis1 mutation (47 available)
Fis1tm1Dcc mutation (0 available); any Fis1 mutation (47 available)
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:309044 )
• no spermatozoa in epididymides
abnormal spermatid morphology ( J:309044 )
• impaired acrosome development and failure to produce elongated spermatids
multinucleated giant male germ cells ( J:309044 )
• with increased mitochondria content
increased male germ cell apoptosis ( J:309044 )
• 4-fold increase in tubules

cellular
azoospermia ( J:309044 )
• no spermatozoa in epididymides
abnormal spermatid morphology ( J:309044 )
• impaired acrosome development and failure to produce elongated spermatids
multinucleated giant male germ cells ( J:309044 )
• with increased mitochondria content
increased mitochondrial number ( J:309044 )
• in round spermatids and giant cells
impaired autophagy ( J:309044 )
• in round spermatids and giant cells with aberrant accumulation of autophagic structures
increased male germ cell apoptosis ( J:309044 )
• 4-fold increase in tubules

homeostasis/metabolism
impaired autophagy ( J:309044 )
• in round spermatids and giant cells with aberrant accumulation of autophagic structures

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory