Phenotypes associated with this allele

• Allele Symbol: Strip2^tm1.2Tac
• Allele Name: targeted mutation 1.2, Taconic
• Allele ID: MGI:6755525
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Strip2^tm1.2Tac/Strip2^tm1.2Tac	Not Specified	MGI:6756378

Genotype
MGI:6756378

hm1

• Allelic Composition: Strip2^tm1.2Tac/Strip2^tm1.2Tac
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:306481 )

N • normal blood pressure, heart rate and cardiomyocyte morphology

N • no ventricular enlargement

decreased cardiac muscle contractility ( J:306481 )

• progressively reduced fractional shortening starting at age 8 weeks

shortened QT interval ( J:306481 )

♀ • significant shortening of QT and corrected QTc interval

muscle

decreased cardiac muscle contractility ( J:306481 )

• progressively reduced fractional shortening starting at age 8 weeks

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:306481 )

• increased cardiac hypertrophy (increased cardiomyocyte size) after trans-aortic constriction (TAC)-induced pressure overload

• increased cardiac fibrosis after TAC-induced pressure overload

• more severely reduced fractional shortening after TAC-induced pressure overload

• increased end-diastolic diameter after TAC-induced pressure overload

reproductive system

reproductive system phenotype ( J:306481 )

N • fertile