Phenotypes associated with this allele

• Allele Symbol: Sox9^{em1(cre/ERT2)Smoc}
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6758059
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox9^em1(cre/ERT2)Smoc/Sox9^+ Tnfsf18^em1Pwan/Tnfsf18^em1Pwan	involves: C57BL/6J	MGI:7621581

Genotype
MGI:7621581

cn1

• Allelic Composition: Sox9^{em1(cre/ERT2)Smoc}/Sox9⁺; Tnfsf18^em1Pwan/Tnfsf18^em1Pwan
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show reduced serum levels of alanine transaminase, indicating reduced liver injury compared to controls

decreased circulating aspartate transaminase level ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show reduced serum levels of aspartate aminotransferase, indicating reduced liver injury compared to controls

abnormal response to injury ( J:346395 )

♂ • mice injected with tamoxifen at 8 weeks of age, followed by a 2 weeks of tamoxifen washout, and then fed a choline-deficient diet supplemented with ethionine (CDE) to induce liver injury (activates liver progenitor cells by transiently inhibiting hepatocyte proliferation) exhibit attenuated ductular reaction, liver inflammation, and liver fibrosis

immune system

decreased CD8-positive, alpha-beta T cell number ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show a reduction in the proportion of liver-infiltrating CD8+ T lymphocytes and glucocorticoid-induced tumor necrosis factor receptor (GITR)-positive CD8+ T lymphocytes

abnormal T cell activation ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show no increase in GITR+ proportion of CD45+CD3+ T lymphocytes after a 9 week CDE diet, indicating lowered numbers of activated CD45+CD3+ T lymphocytes

decreased inflammatory response ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show attenuated liver inflammation, with reduced liver-infiltrating CD8+ T lymphocytes, no increase in the proportion of activated CD45+CD83+ T lymphocytes, no reduction in the proportion of CD4+ T lymphocytes, and reduced immune cells around the portal area at 9 weeks after CDE injury

liver/biliary system

decreased hepatoblast number ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show reduced proportion of GITRL+Sox9+ and EpCAM+Sox9+ liver progenitor cells among the CD45- liver nonparenchymal cells

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show a reduction in the proportion of liver-infiltrating CD8+ T lymphocytes and glucocorticoid-induced tumor necrosis factor receptor (GITR)-positive CD8+ T lymphocytes

abnormal T cell activation ( J:346395 )

♂ • mice injected with tamoxifen and fed the CDE-diet show no increase in GITR+ proportion of CD45+CD3+ T lymphocytes after a 9 week CDE diet, indicating lowered numbers of activated CD45+CD3+ T lymphocytes