Phenotypes associated with this allele

• Allele Symbol: Specc1l^em1Kumc
• Allele Name: endonuclease-mediated mutation 1, University of Kansas Medical Center
• Allele ID: MGI:6758245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Specc1l^em1Kumc/Specc1l^tm1Kumc	involves: 129S6/SvEvTac	MGI:7354948

Genotype
MGI:7354948

ht1

• Allelic Composition: Specc1l^em1Kumc/Specc1l^tm1Kumc
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:300385 )

craniofacial

abnormal secondary palate development ( J:300385 )

• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue

• during elevation the posterior plate advances prior to middle and anterior plates

• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance

• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams

delayed palatal shelf elevation ( J:300385 )

• delayed at E14.5 but in most cases shelves fuse by E15.5

digestive/alimentary system

abnormal secondary palate development ( J:300385 )

• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue

• during elevation the posterior plate advances prior to middle and anterior plates

• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance

• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams

delayed palatal shelf elevation ( J:300385 )

• delayed at E14.5 but in most cases shelves fuse by E15.5

growth/size/body

abnormal secondary palate development ( J:300385 )

• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue

• during elevation the posterior plate advances prior to middle and anterior plates

• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance

• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams

delayed palatal shelf elevation ( J:300385 )

• delayed at E14.5 but in most cases shelves fuse by E15.5