About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Specc1ltm1Kumc
targeted mutation 1, University of Kansas Medical Center
MGI:6758246
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Specc1lem1Kumc/Specc1ltm1Kumc involves: 129S6/SvEvTac MGI:7354948


Genotype
MGI:7354948
ht1
Allelic
Composition
Specc1lem1Kumc/Specc1ltm1Kumc
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Specc1lem1Kumc mutation (0 available); any Specc1l mutation (51 available)
Specc1ltm1Kumc mutation (0 available); any Specc1l mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue
• during elevation the posterior plate advances prior to middle and anterior plates
• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance
• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams
• delayed at E14.5 but in most cases shelves fuse by E15.5

digestive/alimentary system
• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue
• during elevation the posterior plate advances prior to middle and anterior plates
• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance
• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams
• delayed at E14.5 but in most cases shelves fuse by E15.5

growth/size/body
• at E14.5 the palatal shelves are acutely angled and do not move immediately inwards to occupy the space above the tongue
• during elevation the posterior plate advances prior to middle and anterior plates
• in culture, embryonic palatal mesenchyme cells show reduced migration speed of wound fronts, overall reduction in motile activity, and impaired guidance
• decrease in correlation length values in high density areas suggests impaired ability of palate mesenchymal cells to form streams
• delayed at E14.5 but in most cases shelves fuse by E15.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory