All Phenotypes Tg(Umod*C217G)1Xrw MGI Mouse

premature death ( J:252420 )

• mice begin to succumb to death at around 12 months of age

increased renal tubule apoptosis ( J:252420 )

• apoptosis is increased in the kidney thick ascending limb cells in 12-month-old mice but not in 1-month-old mice

• 1-month old mice have more diluted urine, with lower osmolality and lower concentrations of all the electrolytes, including sodium, calcium, potassium, chloride, phosphorus, citrate, and magnesium

increased urine osmolality ( J:252420 )

• 12-month-old mice have a higher urine osmolality and lower 24-hour excretion of all the electrolytes

increased urine uric acid level ( J:252420 )

• both young and old mice show increased serum uric acid levels

• both young and old mice show elevated levels of serum allantoin, the catabolic product of uric acid

glomerulosclerosis ( J:252420 )

• sclerotic glomeruli are present in the cortex of 12-month-old mice

renal interstitial fibrosis ( J:252420 )

• mice at 12 months of age exhibit interstitial fibrosis in medullary and papillary regions

• an increase in collagen deposition in the kidneys is seen in young (1 month of age) mice and more so in old (12 months of age) mice

renal tubule atrophy ( J:252420 )

• mice at 12 months of age exhibit extensive atrophic tubules

decreased creatinine clearance ( J:252420 )

• 6- and 12-month-old mice show decreased creatinine clearance rate

decreased renal glomerular filtration rate ( J:252420 )

kidney failure ( J:252420 )

oliguria ( J:252420 )

• by 6 months of age, mice have about 1/3 the urine output of wild-type mice and at 12 months of age, mice have about 1/5 of the urine volume of wild-type mice

polyuria ( J:252420 )

• urine volume of 1-month old mice is more than 2-fold higher than in wild-type mice

• however, this increase is reversed as early as 3 months of age