Phenotypes associated with this allele

• Allele Symbol: Fignl2^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:6758815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fignl2^tm1.1Geno/Fignl2^tm1.1Geno	involves: C57BL/6	MGI:6758816

Genotype
MGI:6758816

cn1

• Allelic Composition: Fignl2^tm1.1Geno/Fignl2^tm1.1Geno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:309596 )

• regenerating dorsal root ganglion (DRG) axons from neurons transduced with adenovirus containing cre recombinase (Ad-cre) challenged with a mixture of chondroitin sulfate proteoglycans (an inhibitory environmental cue) show a higher percentage of neurites that cross through the borders containing the inhibitory chondroitin sulfate proteoglycans compared to controls, indicating attenuated growth cone retraction in response to inhibitory molecules

abnormal neurite morphology ( J:309596 )

• the sum length of neurite outgrowth is increased in Ad-cre-treated dorsal root ganglion neurons, however the average numbers of primary, secondary, and tertiary neurites are not significantly altered

• DRG neurons transduced with Ad-cre show an increase in the average ratio of dynamic to total microtubules in the distalmost segment of regenerating neurites

• DRG neurons transduced with Ad-cre show no increase in growth cone collapse in the presence of recombinant semaphorin 3A, a chemorepellent during the development of the nervous system

abnormal axon morphology ( J:309596 )

• adult dorsal root ganglion (DRG) neurons transduced ex vivo with an adenovirus containing cre recombinase (Ad-cre) to excise the gene exhibit longer axons when grown in culture, with a mean axon length approximately 50% longer than control neurons

abnormal neuron physiology ( J:309596 )

• DRG neurons transduced with Ad-cre show no increase in growth cone collapse in the presence of recombinant semaphorin 3A, a chemorepellent during the development of the nervous system

cellular

abnormal axon extension ( J:309596 )

• regenerating dorsal root ganglion (DRG) axons from neurons transduced with adenovirus containing cre recombinase (Ad-cre) challenged with a mixture of chondroitin sulfate proteoglycans (an inhibitory environmental cue) show a higher percentage of neurites that cross through the borders containing the inhibitory chondroitin sulfate proteoglycans compared to controls, indicating attenuated growth cone retraction in response to inhibitory molecules