About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kctd19em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6758821
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kctd19em1Osb/Kctd19em1Osb Not Specified MGI:6759017
cx2
 		Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)HAOsb/0 		Not Specified MGI:6759020
cx3
 		Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)FLAGOsb/0
Tg(Clgn-Kctd19)HAOsb/0 		Not Specified MGI:6759022


Genotype
MGI:6759017
hm1
Allelic
Composition		 Kctd19em1Osb/Kctd19em1Osb
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd19em1Osb mutation (6 available); any Kctd19 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:306305 )
N
• normal litters when mated to heterozygote mutant males
azoospermia ( J:306305 )
• no mature spermatozoa in cauda epididymis
abnormal spermatid morphology ( J:306305 )
• round spermatids virtually absent from seminiferous tubules
abnormal male meiosis ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
arrest of male meiosis ( J:306305 )
• no progress of spermatocytes beyond leptotene (stage X-XI)
• increased number of misaligned chromosomes in metaphase spermatocytes
• normal spermatid nuclear morphology (meiotic progress) up to leptotene (stage X-XI)
• normal number of bivalent chromosomes with chiasmata in metaphase spermatocytes
abnormal synaptonemal complex ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
increased primordial germ cell apoptosis ( J:306305 )
• in stage II-V and X-XII seminiferous tubules
decreased testis weight ( J:306305 )
• significantly reduced testis-to-body weight ratio
male infertility ( J:306305 )
• no offspring when mated to wild-type females

endocrine/exocrine glands
decreased testis weight ( J:306305 )
• significantly reduced testis-to-body weight ratio

cellular
azoospermia ( J:306305 )
• no mature spermatozoa in cauda epididymis
abnormal spermatid morphology ( J:306305 )
• round spermatids virtually absent from seminiferous tubules
abnormal male meiosis ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
arrest of male meiosis ( J:306305 )
• no progress of spermatocytes beyond leptotene (stage X-XI)
• increased number of misaligned chromosomes in metaphase spermatocytes
• normal spermatid nuclear morphology (meiotic progress) up to leptotene (stage X-XI)
• normal number of bivalent chromosomes with chiasmata in metaphase spermatocytes
abnormal synaptonemal complex ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
increased primordial germ cell apoptosis ( J:306305 )
• in stage II-V and X-XII seminiferous tubules

embryo
embryo phenotype ( J:306305 )
N
• normal development

mortality/aging
mortality/aging ( J:306305 )
N
• viable

behavior/neurological
behavior/neurological phenotype ( J:306305 )
N
• normal behavior




Genotype
MGI:6759020
cx2
Allelic
Composition		 Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)HAOsb/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd19em1Osb mutation (6 available); any Kctd19 mutation (52 available)
Tg(Clgn-Kctd19)HAOsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:306305 )
N
• normal fertility when mated with wild-type female
• normal testis-to-body weight ratio
• normal spermatogenesis




Genotype
MGI:6759022
cx3
Allelic
Composition		 Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)FLAGOsb/0
Tg(Clgn-Kctd19)HAOsb/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd19em1Osb mutation (6 available); any Kctd19 mutation (52 available)
Tg(Clgn-Kctd19)FLAGOsb mutation (0 available)
Tg(Clgn-Kctd19)HAOsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:306305 )
N
• normal fertility when mated with wild-type female




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory