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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kctd19em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6758821
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kctd19em1Osb/Kctd19em1Osb Not Specified MGI:6759017
cx2
 		Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)HAOsb/0 		Not Specified MGI:6759020
cx3
 		Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)FLAGOsb/0
Tg(Clgn-Kctd19)HAOsb/0 		Not Specified MGI:6759022


Genotype
MGI:6759017
hm1
Allelic
Composition		 Kctd19em1Osb/Kctd19em1Osb
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd19em1Osb mutation (6 available); any Kctd19 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:306305 )
N
• normal litters when mated to heterozygote mutant males
azoospermia ( J:306305 )
• no mature spermatozoa in cauda epididymis
abnormal spermatid morphology ( J:306305 )
• round spermatids virtually absent from seminiferous tubules
abnormal male meiosis ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
arrest of male meiosis ( J:306305 )
• no progress of spermatocytes beyond leptotene (stage X-XI)
• increased number of misaligned chromosomes in metaphase spermatocytes
• normal spermatid nuclear morphology (meiotic progress) up to leptotene (stage X-XI)
• normal number of bivalent chromosomes with chiasmata in metaphase spermatocytes
abnormal synaptonemal complex ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
increased primordial germ cell apoptosis ( J:306305 )
• in stage II-V and X-XII seminiferous tubules
decreased testis weight ( J:306305 )
• significantly reduced testis-to-body weight ratio
male infertility ( J:306305 )
• no offspring when mated to wild-type females

endocrine/exocrine glands
decreased testis weight ( J:306305 )
• significantly reduced testis-to-body weight ratio

cellular
azoospermia ( J:306305 )
• no mature spermatozoa in cauda epididymis
abnormal spermatid morphology ( J:306305 )
• round spermatids virtually absent from seminiferous tubules
abnormal male meiosis ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
arrest of male meiosis ( J:306305 )
• no progress of spermatocytes beyond leptotene (stage X-XI)
• increased number of misaligned chromosomes in metaphase spermatocytes
• normal spermatid nuclear morphology (meiotic progress) up to leptotene (stage X-XI)
• normal number of bivalent chromosomes with chiasmata in metaphase spermatocytes
abnormal synaptonemal complex ( J:306305 )
• increased location of Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in metaphase spermatocytes
increased primordial germ cell apoptosis ( J:306305 )
• in stage II-V and X-XII seminiferous tubules

embryo
embryo phenotype ( J:306305 )
N
• normal development

mortality/aging
mortality/aging ( J:306305 )
N
• viable

behavior/neurological
behavior/neurological phenotype ( J:306305 )
N
• normal behavior




Genotype
MGI:6759020
cx2
Allelic
Composition		 Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)HAOsb/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd19em1Osb mutation (6 available); any Kctd19 mutation (52 available)
Tg(Clgn-Kctd19)HAOsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:306305 )
N
• normal fertility when mated with wild-type female
• normal testis-to-body weight ratio
• normal spermatogenesis




Genotype
MGI:6759022
cx3
Allelic
Composition		 Kctd19em1Osb/Kctd19em1Osb
Tg(Clgn-Kctd19)FLAGOsb/0
Tg(Clgn-Kctd19)HAOsb/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd19em1Osb mutation (6 available); any Kctd19 mutation (52 available)
Tg(Clgn-Kctd19)FLAGOsb mutation (0 available)
Tg(Clgn-Kctd19)HAOsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:306305 )
N
• normal fertility when mated with wild-type female




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory