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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp541em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6758830
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Zfp541em1Osb/Zfp541em1Osb
Tg(CAG-EGFP,Acr-EGFP)2Osb/0 		involves: 129S2/SvPas * C57BL/6NSlc MGI:6759016


Genotype
MGI:6759016
cx1
Allelic
Composition		 Zfp541em1Osb/Zfp541em1Osb
Tg(CAG-EGFP,Acr-EGFP)2Osb/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP,Acr-EGFP)2Osb mutation (5 available)
Zfp541em1Osb mutation (2 available); any Zfp541 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:306305 )
• round spermatids virtually absent from seminiferous tubules
abnormal male meiosis ( J:306305 )
• diffuse location of Sycp1 and Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in late pachytene spermatocytes
abnormal X-Y chromosome synapsis during male meiosis ( J:306305 )
• asynapsis of X and Y chromosomes in early pachytene spermatocytes
arrest of male meiosis ( J:306305 )
• lack of diplotene spermatocytes
abnormal synaptonemal complex ( J:306305 )
• diffuse location of Sycp1 and Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in late pachytene spermatocytes
increased primordial germ cell apoptosis ( J:306305 )
• in stage II-V, VI-IX and X-XII seminiferous tubules

cellular
abnormal spermatid morphology ( J:306305 )
• round spermatids virtually absent from seminiferous tubules
abnormal male meiosis ( J:306305 )
• diffuse location of Sycp1 and Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in late pachytene spermatocytes
abnormal X-Y chromosome synapsis during male meiosis ( J:306305 )
• asynapsis of X and Y chromosomes in early pachytene spermatocytes
arrest of male meiosis ( J:306305 )
• lack of diplotene spermatocytes
abnormal synaptonemal complex ( J:306305 )
• diffuse location of Sycp1 and Sycp3 synaptonemal complex proteins outside of synaptonemal complex axis in late pachytene spermatocytes
increased primordial germ cell apoptosis ( J:306305 )
• in stage II-V, VI-IX and X-XII seminiferous tubules




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory