Phenotypes associated with this allele

• Allele Symbol: Plin5^tm1Macl
• Allele Name: targeted mutation 1, Malin C Levin
• Allele ID: MGI:6758997
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plin5^tm1Macl/Plin5^tm1Macl	involves: 129S6/SvEvTac * C57BL/6JBomTac	MGI:6759008

Genotype
MGI:6759008

hm1

• Allelic Composition: Plin5^tm1Macl/Plin5^tm1Macl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6JBomTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac muscle triglyceride level ( J:286482 )

♂ • triglyceride levels in the heart are lower

abnormal heart morphology ( J:286482 )

♂ • triglyceride and diacylglycerol levels in the heart are lower

♂ • hearts contain a higher percentage of triglycerides with medium-chain fatty acids and lower percentage of triglycerides with long-chain and very-long-chain fatty acids

♂ • lipid droplets are smaller and tend to be less numerous and are not closely associated with mitochondria in hearts

♂ • however, no differences in other glycerolipid species or membrane lipids are seen in the heart

abnormal cardiovascular system physiology ( J:286482 )

♂ • fatty acid uptake is decreased in hearts

♂ • the incorporation of fatty acids into triglycerides is reduced and the incorporation of fatty acids into phospholipids is increased in hearts

♂ • however, no difference in the incorporation of fatty acids into phosphatidic acid and diglycerides in hearts is seen

increased cardiac muscle cell glucose uptake ( J:286482 )

♂ • glucose uptake in hearts is 2-fold higher

decreased cardiac muscle contractility ( J:286482 )

• mice show a modest reduction in ejection fraction under baseline conditions

• however, mice show no differences in heart dimension or stroke volume under baseline conditions

increased response of heart to induced stress ( J:286482 )

• mice treated with beta-adrenergic agonist dobutamine to maximize the heart's capacity, show differences in diastolic dimensions and stroke volume compared to controls

abnormal response to cardiac infarction ( J:286482 )

♂ • mice exhibit dysregulated metabolism in hearts following ischemia, with lower levels of C2 and C4 acylcarnitines after a myocardial infarction induced by ligation of the left anterior descending artery, indicating downregulation of fatty acid oxidation

♂ • accumulation of glycogen is increased in the septum after a myocardial infarction

cellular

increased cardiac muscle cell glucose uptake ( J:286482 )

♂ • glucose uptake in hearts is 2-fold higher

decreased fatty acid oxidation ( J:286482 )

♂ • mice show lower levels of C2 and C4 acylcarnitines after a myocardial infarction induced by ligation of the left anterior descending artery, indicating downregulation of fatty acid oxidation in response to infarction

homeostasis/metabolism

decreased cardiac muscle triglyceride level ( J:286482 )

♂ • triglyceride levels in the heart are lower

increased response of heart to induced stress ( J:286482 )

• mice treated with beta-adrenergic agonist dobutamine to maximize the heart's capacity, show differences in diastolic dimensions and stroke volume compared to controls

abnormal response to cardiac infarction ( J:286482 )

♂ • mice exhibit dysregulated metabolism in hearts following ischemia, with lower levels of C2 and C4 acylcarnitines after a myocardial infarction induced by ligation of the left anterior descending artery, indicating downregulation of fatty acid oxidation

♂ • accumulation of glycogen is increased in the septum after a myocardial infarction

decreased fatty acid oxidation ( J:286482 )

♂ • mice show lower levels of C2 and C4 acylcarnitines after a myocardial infarction induced by ligation of the left anterior descending artery, indicating downregulation of fatty acid oxidation in response to infarction

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:286482 )

• mice exhibit reduced survival after induced myocardial infarction, with mice starting to die at a much higher rate than wild-type mice 3 days after ischemia

muscle

decreased cardiac muscle triglyceride level ( J:286482 )

♂ • triglyceride levels in the heart are lower

increased cardiac muscle cell glucose uptake ( J:286482 )

♂ • glucose uptake in hearts is 2-fold higher

decreased cardiac muscle contractility ( J:286482 )

• mice show a modest reduction in ejection fraction under baseline conditions

• however, mice show no differences in heart dimension or stroke volume under baseline conditions