Phenotypes associated with this allele

• Allele Symbol: Nsrp1^tm1.1Cdj
• Allele Name: targeted mutation 1.1, Chang-Duk Jun
• Allele ID: MGI:6759471
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nsrp1^tm1.1Cdj/Nsrp1^tm1.1Cdj Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2 * SJL	MGI:6759797

Genotype
MGI:6759797

cn1

• Allelic Composition: Nsrp1^tm1.1Cdj/Nsrp1^tm1.1Cdj; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:306261 )

N • normal size of thymus, spleen and lymph nodes

N • normal number of CD4 CD8 double-positive and double-negative thymocytes

N • normal number of TCRB-lo CD69-lo and TCRB-int CD69-int thymocytes

increased T cell apoptosis ( J:306261 )

• increased apoptosis of CD4+ CD8+ CD69+ thymocytes

increased T cell proliferation ( J:306261 )

• increased number of CD4+ CD8+ CD69+ and CD4+ CD8+ CD69- thymocytes in S and G2/M phase of cell cycle

abnormal T cell number ( J:306261 )

• reduced number of TCRB-hi CD69-hi and TCRB-hi CD69-lo thymocytes

• reduced number of CD4+ CD69-hi and CD8+ CD69-hi thymocytes

• reduced number of CD24-lo TCRB-hi CD4+ and CD24-lo TCRB-hi CD8+ thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:306261 )

• reduced number in thymus, spleen and lymph nodes

• normal total number of thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:306261 )

• reduced number in thymus, spleen and lymph nodes

• normal total number of thymocytes

increased memory T cell number ( J:306261 )

• increased number of CD44-hi CD62L-lo and CD44-hi CD62L-hi T cells in spleen and lymph nodes

hematopoietic system

increased T cell apoptosis ( J:306261 )

• increased apoptosis of CD4+ CD8+ CD69+ thymocytes

increased T cell proliferation ( J:306261 )

• increased number of CD4+ CD8+ CD69+ and CD4+ CD8+ CD69- thymocytes in S and G2/M phase of cell cycle

abnormal T cell number ( J:306261 )

• reduced number of TCRB-hi CD69-hi and TCRB-hi CD69-lo thymocytes

• reduced number of CD4+ CD69-hi and CD8+ CD69-hi thymocytes

• reduced number of CD24-lo TCRB-hi CD4+ and CD24-lo TCRB-hi CD8+ thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:306261 )

• reduced number in thymus, spleen and lymph nodes

• normal total number of thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:306261 )

• reduced number in thymus, spleen and lymph nodes

• normal total number of thymocytes

increased memory T cell number ( J:306261 )

• increased number of CD44-hi CD62L-lo and CD44-hi CD62L-hi T cells in spleen and lymph nodes

cellular

increased T cell apoptosis ( J:306261 )

• increased apoptosis of CD4+ CD8+ CD69+ thymocytes

increased T cell proliferation ( J:306261 )

• increased number of CD4+ CD8+ CD69+ and CD4+ CD8+ CD69- thymocytes in S and G2/M phase of cell cycle

mortality/aging

mortality/aging ( J:306261 )

N • viable