Phenotypes associated with this allele

• Allele Symbol: Syce1^em1Rrca
• Allele Name: endonuclease-mediated mutation 1, Rosana Rodriguez-Casuriaga
• Allele ID: MGI:6760662
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syce1^em1Rrca/Syce1^em1Rrca	involves: C57BL/6J	MGI:6760664

Genotype
MGI:6760664

hm1

• Allelic Composition: Syce1^em1Rrca/Syce1^em1Rrca
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent oocytes ( J:309952 )

♀

abnormal chromosomal synapsis ( J:309952 )

• meiotic chromosomes show closely aligned but unsynapsed lateral elements

abnormal ovary morphology ( J:309952 )

♀ • ovaries with deeply altered histology and lack of follicles or oocytes

absent ovarian follicles ( J:309952 )

♀

small ovary ( J:309952 )

♀

small seminiferous tubules ( J:309952 )

♂

small testis ( J:309952 )

♂

abnormal spermatogenesis ( J:309952 )

♂ • severely affected spermatogenesis, with complete absence of postmeiotic stages

azoospermia ( J:309952 )

♂ • males show complete absence of postmeiotic stage spermatids

arrest of male meiosis ( J:309952 )

♂ • seminiferous tubules are depleted of spermatocytes from mid and advanced prophase I stages (pachytene and diplotene), indicating an arrest in early meiotic prophase I stages

infertility ( J:309952 )

• female and male infertility

endocrine/exocrine glands

abnormal ovary morphology ( J:309952 )

♀ • ovaries with deeply altered histology and lack of follicles or oocytes

absent ovarian follicles ( J:309952 )

♀

small ovary ( J:309952 )

♀

small seminiferous tubules ( J:309952 )

♂

small testis ( J:309952 )

♂

cellular

absent oocytes ( J:309952 )

♀

azoospermia ( J:309952 )

♂ • males show complete absence of postmeiotic stage spermatids

abnormal chromosomal synapsis ( J:309952 )

• meiotic chromosomes show closely aligned but unsynapsed lateral elements

arrest of male meiosis ( J:309952 )

♂ • seminiferous tubules are depleted of spermatocytes from mid and advanced prophase I stages (pachytene and diplotene), indicating an arrest in early meiotic prophase I stages

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ovarian insufficiency 12		DOID:0080869	OMIM:616947	J:309952