Phenotypes associated with this allele

• Allele Symbol: Unk^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6761879
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Nes-cre)1Kln/0 Unk^tm1c(KOMP)Wtsi/Unk^tm1c(KOMP)Wtsi	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL	MGI:7331610

Genotype
MGI:7331610

cn1

• Allelic Composition: Tg(Nes-cre)1Kln/0; Unk^{tm1c(KOMP)Wtsi}/Unk^{tm1c(KOMP)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:309451 )

N • mice show similar locomotor activity in the open field and elevated plus maze as controls, perform similarly to controls in the Y maze and in the Morris water maze indicating normal short-term spatial memory and acquisition learning and reference memory, respectively, and show a non-significant trend towards decreased anxiety

abnormal cognition ( J:309451 )

• in the Morris water maze reversal learning test, mice show reduced latency to find the platform and spend more time in the probe quadrant and turn significantly more acutely towards the probe quadrant indicating enhanced memory formation and cognitive flexibility to re-learn

growth/size/body

decreased body weight ( J:309451 )

• adult mice weigh slightly less than controls

nervous system

nervous system phenotype ( J:309451 )

N • neuroanatomy of the brain appears normal at E16.5 and neurogenesis and overall brain development appears unaffected

N • neuroanatomy of the mature brain appears normal