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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox10tm1Ngan
targeted mutation 1, Elly S W Ngan
MGI:6762161
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox10tm1Ngan/Sox10tm1Ngan involves: 129S/SvEv * C57BL/6 MGI:7451337
ht2
 		Sox10tm1Ngan/Sox10+ involves: 129S/SvEv * C57BL/6 MGI:7451333
cn3
 		Sox10tm1Ngan/Sox10+
Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA MGI:7451336
cn4
 		Sox10tm1Ngan/Sox10+
Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * C57BL/6 * CBA MGI:7451340


Genotype
MGI:7451337
hm1
Allelic
Composition		 Sox10tm1Ngan/Sox10tm1Ngan
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• ~2x larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:7451333
ht2
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:7451336
cn3
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (32 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:7451340
cn4
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
Sox9tm1.1Ksec mutation (0 available); any Sox9 mutation (32 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• ~2.7x larger cross-section of basal cochlear lumen in E15.5 embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory