Phenotypes associated with this allele

• Allele Symbol: Colgalt2^tm1.1Hwei
• Allele Name: targeted mutation 1.1, Hongshan Wei
• Allele ID: MGI:6763172
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Colgalt2^tm1.1Hwei/Colgalt2^tm1.1Hwei	involves: C57BL/6J	MGI:6856872

Genotype
MGI:6856872

hm1

• Allelic Composition: Colgalt2^tm1.1Hwei/Colgalt2^tm1.1Hwei
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:310468 )

• apoptosis rate of primary CD4+ T cells after Con A challenge for 6, 12, and 24 hours is increased compared to wild-type mice

abnormal regulatory T cell morphology ( J:310468 )

• Con A administered mice show an increase in the frequency of the CD25^-CD69+ subset of CD4+ T cells in the blood 24 hours after challenge

• Con A administered mice show an increase in the frequency of the CD25^-CD69⁺ subset of CD4+ T cells in the spleen only 12 hours after challenge

• mice show increased frequency of CD25⁺CD69^- subset but decreased frequency of the CD25^-CD69⁺ subset in primary CD4+ T cells following Con A challenge for 0, 6, 12, and 24 hours compared to wild-type CD4+ T cells

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:310468 )

• Con A administered mice show a decrease in the frequency of the CD25⁺CD69⁺ subset of CD4+ T cells in the blood 12 hours after challenge

• mice show increased frequency of CD25⁺CD69^- subset in primary CD4+ T cells following Con A challenge for 0, 6, 12, and 24 hours compared to wild-type CD4+ T cells

increased circulating interleukin-1 beta level ( J:310468 )

• serum IL-1beta levels are increased after Con A challenge for 6 or 12 hours

• however, no differences in IL-17, IL-23, IL-27, IL 12p70, MCP-3, MIP-1a, MIP-1b, and RNATES levels after Con A challenge are seen

increased circulating interleukin-4 level ( J:310468 )

• serum IL-4 levels are increased after Con A challenge for 6, 12, or 24 hours

increased circulating interleukin-6 level ( J:310468 )

• serum IL-6 levels are increased after Con A challenge for 6, 12, or 24 hours

increased circulating interleukin-9 level ( J:310468 )

• serum IL-9 levels are increased after Con A challenge for 6, 12, or 24 hours, whereas they are decreased in wild-type mice after a 12-hour challenge

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:310468 )

• serum IL-1beta levels are increased after Con A challenge for 6 or 12 hours

• however, no differences in IL-17, IL-23, IL-27, IL 12p70, MCP-3, MIP-1a, MIP-1b, and RNATES levels after Con A challenge are seen

increased circulating interleukin-4 level ( J:310468 )

• serum IL-4 levels are increased after Con A challenge for 6, 12, or 24 hours

increased circulating interleukin-6 level ( J:310468 )

• serum IL-6 levels are increased after Con A challenge for 6, 12, or 24 hours

increased circulating interleukin-9 level ( J:310468 )

• serum IL-9 levels are increased after Con A challenge for 6, 12, or 24 hours, whereas they are decreased in wild-type mice after a 12-hour challenge

increased circulating alanine transaminase level ( J:310468 )

• alanine transaminase (ALT) levels are increased at baseline

• after Con A challenge for 6 or 12 hours, the increase in ALT levels is even more significant than in unchallenged mice

increased susceptibility to injury ( J:310468 )

• mice treated with concanavalin A (Con A) to induce liver injury/hepatitis exhibit more extensive hepatocellular damage than in wild-type mice, with presence of a severely collapsing liver plate

• the liver injury scores are increased after Con A challenge for 12 hours, but there are no differences in injury scores after Con A challenge for 6 or 24 hours

hematopoietic system

increased T cell apoptosis ( J:310468 )

• apoptosis rate of primary CD4+ T cells after Con A challenge for 6, 12, and 24 hours is increased compared to wild-type mice

abnormal regulatory T cell morphology ( J:310468 )

• Con A administered mice show an increase in the frequency of the CD25^-CD69+ subset of CD4+ T cells in the blood 24 hours after challenge

• Con A administered mice show an increase in the frequency of the CD25^-CD69⁺ subset of CD4+ T cells in the spleen only 12 hours after challenge

• mice show increased frequency of CD25⁺CD69^- subset but decreased frequency of the CD25^-CD69⁺ subset in primary CD4+ T cells following Con A challenge for 0, 6, 12, and 24 hours compared to wild-type CD4+ T cells

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:310468 )

• Con A administered mice show a decrease in the frequency of the CD25⁺CD69⁺ subset of CD4+ T cells in the blood 12 hours after challenge

• mice show increased frequency of CD25⁺CD69^- subset in primary CD4+ T cells following Con A challenge for 0, 6, 12, and 24 hours compared to wild-type CD4+ T cells

cellular

increased T cell apoptosis ( J:310468 )

• apoptosis rate of primary CD4+ T cells after Con A challenge for 6, 12, and 24 hours is increased compared to wild-type mice