Phenotypes associated with this allele

• Allele Symbol: Spink7^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6764496
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spink7^em1Cya/Spink7^em1Cya	C57BL/6N-Spink7^em1Cya/Cya	MGI:6764499

Genotype
MGI:6764499

hm1

• Allelic Composition: Spink7^em1Cya/Spink7^em1Cya
• Genetic Background: C57BL/6N-Spink7^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:310883 )

• in a 5-day DSS model, mice exhibit impaired recovery of colitis compared with wild-type mice

• in a 7-day DSS model, mice exhibit increased body weight loss, higher disease activity index, more shortening of colon length, more extensive ulcers, and increased crypt loss compared with wild-type mice

increased interleukin-1 beta secretion ( J:310883 )

• in mice treated with DSS for 5 days

increased interleukin-6 secretion ( J:310883 )

• in mice treated with DSS for 5 days

growth/size/body

increased susceptibility to weight loss ( J:310883 )

• in a 7-day DSS model

digestive/alimentary system

increased susceptibility to induced colitis ( J:310883 )

• in a 5-day DSS model, mice exhibit impaired recovery of colitis compared with wild-type mice

• in a 7-day DSS model, mice exhibit increased body weight loss, higher disease activity index, more shortening of colon length, more extensive ulcers, and increased crypt loss compared with wild-type mice