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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pms2tm1.1Sks
targeted mutation 1.1, Shyam Sharan
MGI:6764550
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pms2tm1.1Sks/Pms2tm1.1Sks involves: 129S4/SvJae * C57BL/6J MGI:6764551
cx2
 		Apctm1Rak/Apc+
Pms2tm1.1Sks/Pms2tm1.1Sks 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J MGI:6764552


Genotype
MGI:6764551
hm1
Allelic
Composition		 Pms2tm1.1Sks/Pms2tm1.1Sks
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pms2tm1.1Sks mutation (0 available); any Pms2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:310354 )
N
• mice exhibit normal fertility with normal male testis morphology, sperm count, and meiotic progression




Genotype
MGI:6764552
cx2
Allelic
Composition		 Apctm1Rak/Apc+
Pms2tm1.1Sks/Pms2tm1.1Sks
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rak mutation (1 available); any Apc mutation (158 available)
Pms2tm1.1Sks mutation (0 available); any Pms2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
intestine polyps ( J:310354 )
• mice exhibit increased intestinal polyp formation with microsatellite instability compared with Apctm1Rak heterozygotes
• however, morphology of polyps is the same as in Apctm1Rak heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory