Phenotypes associated with this allele

• Allele Symbol: Nmi^em1Hhl
• Allele Name: endonuclease-mediated mutation 1, Huanhuan Liang
• Allele ID: MGI:6764595
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmi^em1Hhl/Nmi^em1Hhl	C57BL/6-Nmi^em1Hhl	MGI:6764602

Genotype
MGI:6764602

hm1

• Allelic Composition: Nmi^em1Hhl/Nmi^em1Hhl
• Genetic Background: C57BL/6-Nmi^em1Hhl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:298909 )

• after LPS intraperitoneal injection

immune system

decreased circulating interleukin-6 level ( J:298909 )

• 3 h after LPS and D-gal intraperitoneal injection

• 6 h after LPS and acetaminophen intraperitoneal injection

• 24 h after LPS intraperitoneal injection

decreased circulating tumor necrosis factor level ( J:298909 )

• 3 h after LPS and D-gal intraperitoneal injection

• 24 h after LPS and acetaminophen intraperitoneal injection

• 24 h after LPS intraperitoneal injection

decreased susceptibility to endotoxin shock ( J:298909 )

• mice intraperitoneally injection with LPS alone or in conjunction with D-gal or acetaminophen exhibit improved survival and reduced serum TNF, IL6, aspartate transaminase, and alanine transaminase levels compared with wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:298909 )

• after LPS intraperitoneal injection

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:298909 )

• 3 h after LPS and D-gal intraperitoneal injection

• 6 h after LPS and acetaminophen intraperitoneal injection

• 24 h after LPS intraperitoneal injection

decreased circulating tumor necrosis factor level ( J:298909 )

• 3 h after LPS and D-gal intraperitoneal injection

• 24 h after LPS and acetaminophen intraperitoneal injection

• 24 h after LPS intraperitoneal injection

decreased circulating alanine transaminase level ( J:298909 )

• after LPS intraperitoneal injection

decreased circulating aspartate transaminase level ( J:298909 )

• after LPS intraperitoneal injection