Phenotypes associated with this allele

• Allele Symbol: Ifi35^em1Hhl
• Allele Name: endonuclease-mediated mutation 1, Huanhuan Liang
• Allele ID: MGI:6764596
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifi35^em1Hhl/Ifi35^em1Hhl	C57BL/6-Ifi35^em1Hhl	MGI:6764604

Genotype
MGI:6764604

hm1

• Allelic Composition: Ifi35^em1Hhl/Ifi35^em1Hhl
• Genetic Background: C57BL/6-Ifi35^em1Hhl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:298909 )

• after LPS intraperitoneal injection

immune system

decreased circulating interleukin-6 level ( J:298909 )

• after LPS intraperitoneal injection

decreased circulating tumor necrosis factor level ( J:298909 )

• after LPS intraperitoneal injection

decreased susceptibility to endotoxin shock ( J:298909 )

• improved survival after LPS intraperitoneal injection and reduced serum TNF and IL6 levels compared with wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:298909 )

• after LPS intraperitoneal injection

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:298909 )

• after LPS intraperitoneal injection

decreased circulating tumor necrosis factor level ( J:298909 )

• after LPS intraperitoneal injection