Phenotypes associated with this allele

• Allele Symbol: Or55b10^tm1Tboz
• Allele Name: targeted mutation 1, Thomas Bozza
• Allele ID: MGI:6766439
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr82^em1Tboz/Rr82^em1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766459
cx2	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr86^em1Tboz/Rr86^em1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766460
cx3	Or55b10^tm1Tboz/Or55b10^tm1Tboz Rr87^em1Tboz/Rr87^em1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766461
cx4	Del(7)3Tboz/Del(7)3Tboz Or55b10^tm1Tboz/Or55b10^tm1Tboz	involves: 129S6/SvEv * C57BL/6J	MGI:6766462

Genotype
MGI:6766459

cx1

• Allelic Composition: Or55b10^tm1Tboz/Or55b10^tm1Tboz; Rr82^em1Tboz/Rr82^em1Tboz
• Genetic Background: involves: 129S6/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

impaired olfaction ( J:310034 )

• homozygous loss of this enhancer results in a lack of aversion to carboxylic acids

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• in the absence of this enhancer there is reduced expression of 70 out of 131 class I olfactory receptor genes, with expression of 18 of those receptors being abolished, and the effect correlates with genomic distance with no genes outside of the class I olfactory receptor cluster being affected

Genotype
MGI:6766460

cx2

• Allelic Composition: Or55b10^tm1Tboz/Or55b10^tm1Tboz; Rr86^em1Tboz/Rr86^em1Tboz
• Genetic Background: involves: 129S6/SvEv * C57BL/6J

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease expression of Olfr577

Genotype
MGI:6766461

cx3

• Allelic Composition: Or55b10^tm1Tboz/Or55b10^tm1Tboz; Rr87^em1Tboz/Rr87^em1Tboz
• Genetic Background: involves: 129S6/SvEv * C57BL/6J

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• homozygous deletion of this enhancer does not decrease Olfr545 expression but does decrease Olfr571 expression

Genotype
MGI:6766462

cx4

• Allelic Composition: Del(7)3Tboz/Del(7)3Tboz; Or55b10^tm1Tboz/Or55b10^tm1Tboz
• Genetic Background: involves: 129S6/SvEv * C57BL/6J

craniofacial

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

growth/size/body

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

nervous system

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

respiratory system

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression

taste/olfaction

abnormal olfactory receptor morphology ( J:310034 )

• 77 of the intact class I olfactory receptor genes have reduced expression