Analysis Tools
liver/biliary system
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• mice exposed to CCL4 exhibit reduced hepatic infiltration compared with wild-type mice
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homeostasis/metabolism
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• in mice exposed to CCL4
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• in mice exposed to CCL4
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• in mice exposed to CCL4 or subjected to bile duct ligation
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• in mice exposed to CCL4
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• mice exposed to CCL4 exhibit attenuated livery injury, fibrosis with reduced alanine transferase (ALT) levels, reduced hepatic infiltration, M1 polarization, proinflammatory cytokine (TNF, IL6, and TGFbeta) production, and increased hematopoietic stem cell apoptosis compared with wild-type mice
• mice subjected to bile duct ligation exhibit reduced liver fibrosis and circulating alanine transaminase level compared with wild-type mice
• mice fed a 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet exhibit reduced liver fibrosis compared with wild-type mice
• however, DDC-treated mice exhibit similar ALT as DDC-treated wild-type mice and restoring endogenous expression restores sensitivity to liver fibrosis
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immune system
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• mice exposed to CCL4 exhibit M1 polarization compared with wild-type mice
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• in mice exposed to CCL4
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• in mice exposed to CCL4
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• mice exposed to CCL4 exhibit reduced hepatic infiltration compared with wild-type mice
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hematopoietic system
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• mice exposed to CCL4 exhibit M1 polarization compared with wild-type mice
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• increased apoptosis in cells from mice exposed to CCL4
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cellular
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• mice exposed to CCL4 exhibit M1 polarization compared with wild-type mice
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