Phenotypes associated with this allele

• Allele Symbol: Slc37a2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:6771481
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc37a2^tm1Dgen/Slc37a2^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:6771482

Genotype
MGI:6771482

hm1

• Allelic Composition: Slc37a2^tm1Dgen/Slc37a2^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:311521 )

• bone marrow-derived macrophages treated with LPS produce increased pro-inflammatory cytokines (TNF, IL6, and IL1B) than wild-type cells

• resting and LPS-treated macrophages exhibit accelerated glycolysis and enhanced mitochondrial oxidative phosphorylation compared with wild-type cells

increased interleukin-1 beta secretion ( J:311521 )

• from bone marrow-derived macrophages treated with LPS

increased interleukin-6 secretion ( J:311521 )

• from bone marrow-derived macrophages treated with LPS, Pam3CSK4, poly(I:C), loxoribine, or CpG

increased tumor necrosis factor secretion ( J:311521 )

• from bone marrow-derived macrophages treated with LPS, Pam3CSK4, poly(I:C), loxoribine, or CpG

increased susceptibility to endotoxin shock ( J:311521 )

• bone marrow-derived macrophages treated with LPS produce increased pro-inflammatory cytokines (TNF, IL6, and IL1B) than wild-type cells

hematopoietic system

abnormal macrophage physiology ( J:311521 )

• bone marrow-derived macrophages treated with LPS produce increased pro-inflammatory cytokines (TNF, IL6, and IL1B) than wild-type cells

• resting and LPS-treated macrophages exhibit accelerated glycolysis and enhanced mitochondrial oxidative phosphorylation compared with wild-type cells