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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnah10em2Yxc
endonuclease-mediated mutation 1, Yunxia Cao
MGI:6780039
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnah10em2Yxc/Dnah10em2Yxc involves: C57BL/6 MGI:6780173


Genotype
MGI:6780173
hm1
Allelic
Composition		 Dnah10em2Yxc/Dnah10em2Yxc
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnah10em2Yxc mutation (0 available); any Dnah10 mutation (175 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:311550 )
• no significant difference in testes weight or size compared to heterozygous controls
• females are fertile and litter size is similar to controls
abnormal spermatogenesis ( J:311550 )
• absence of elongated tails in stage VIIVIII seminiferous tubules
abnormal sperm flagellum morphology ( J:311550 )
• sperm display multiple abnormalities including absent, coiled, short, and irregular flagella
• display disorganized mitochondrial sheath, outer dense fibers, and microtubules
male infertility ( J:311550 )
• complete infertility in males

cellular
abnormal sperm flagellum morphology ( J:311550 )
• sperm display multiple abnormalities including absent, coiled, short, and irregular flagella
• display disorganized mitochondrial sheath, outer dense fibers, and microtubules

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
spermatogenic failure DOID:0111910 OMIM:PS258150
 J:311550




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory