Analysis Tools
mortality/aging
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• 44.4% of neonates die within 72 hours of birth
• another 11.1% of mice exhibit growth retardation and die before P14
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growth/size/body
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• in severe cases, no nasal septum is seen in mice that die within 72 hours of birth
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• in mice that die within 72 hours of birth
• all pups that survive post 72 hours contain normal nasal septum at P4
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• in mice that die within 72 hours of birth
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• 11.1% of mice exhibit growth retardation before P14
• small body size and delayed body weight gain in mice that survive 72 hours but die before P14
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craniofacial
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• penetrance of skeletal defects ranges from 42.8 to 61.1%
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• mice exhibit a loss of branches of the ala temporalis
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• incomplete fusion of the basisphenoid bone in neonates that die within 72 hours of birth
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• the palatine is thinner
• all pups that survive post 72 hours contain normal palatine at P4
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• in severe cases, no nasal septum is seen in mice that die within 72 hours of birth
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• in mice that die within 72 hours of birth
• all pups that survive post 72 hours contain normal nasal septum at P4
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• in mice that die within 72 hours of birth
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skeleton
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• mice exhibit a loss of branches of the ala temporalis
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• incomplete fusion of the basisphenoid bone in neonates that die within 72 hours of birth
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• the palatine is thinner
• all pups that survive post 72 hours contain normal palatine at P4
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• mice exhibit less mineralization of the parietal bone, temporal bone, and supraoccipital bone
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behavior/neurological
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• neonates that die within 72 hours after birth exhibit lower amounts or no milk in their stomachs
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cellular
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• progressive increase in apoptosis in the rostral cephalic region in embryos at E9, E9.5, and E10; the increase in apoptotic cells is restricted temporally to the period between E9 and E10
• however, no difference in cell proliferation is seen in the rostral or caudal cephalic/trunk
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embryo
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• progressive increase in apoptosis in the rostral cephalic region in embryos at E9, E9.5, and E10; the increase in apoptotic cells is restricted temporally to the period between E9 and E10
• however, no difference in cell proliferation is seen in the rostral or caudal cephalic/trunk
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respiratory system
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• in severe cases, no nasal septum is seen in mice that die within 72 hours of birth
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• in mice that die within 72 hours of birth
• all pups that survive post 72 hours contain normal nasal septum at P4
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• in mice that die within 72 hours of birth
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nervous system
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• mutants show no difference in neuronal innervation in the intestine and gross morphology of cerebral cortex, hippocampus, eye, olfactory bulb, cerebellum, and spinal cord is normal at P1
• developing nervous system in E10.5 embryos shows no abnormalities
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