Analysis Tools
mortality/aging
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• embryos die at around E10.5-E11, with embryos becoming fragile and resorbed by E11.5
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growth/size/body
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• embryos are smaller at E10.5
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embryo
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• E10.5 embryos contain fewer somites than wild-type embryos, indicating that growth is arrested around E10
• however, gross morphology, cardiovascular development, the number of somites and blood flow at E9.5 appear normal
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• embryos are smaller at E10.5
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• at E9.5 and E10.5, branching morphogenesis of the chorionic plate and subsequent invasion of the fetal blood vessels are abrogated
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• failure of the functional labyrinth layer to form in the placenta
• however, placenta shows normal morphology at E8.5 and chorioallantoic attachment occurs normally
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• from E9.5 to E10.5, the basal chorionic trophoblast does not undergo any morphological changes or exhibit signs of differentiation such as numerous mitochondria, large electron-dense globules or multi-nucleated syncytia as seen in controls
• at E10.5, the chorionic trophoblast cells remain unfused and undifferentiated
• however, the morphology, growth, and distribution of the spongiotrophoblast and trophoblast giant cells appear normal
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