Phenotypes associated with this allele

• Allele Symbol: 2500002B13Rik^{tm1(CAG-2500002B13Rik)Yo}
• Allele Name: targeted mutation 1, Yuichi Oike
• Allele ID: MGI:6782388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	2500002B13Rik^tm1(CAG-2500002B13Rik)Yo/2500002B13Rik^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:6782390

Genotype
MGI:6782390

ht1

• Allelic Composition: 2500002B13Rik^{tm1(CAG-2500002B13Rik)Yo}/2500002B13Rik⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased response of heart to induced stress ( J:311513 )

• following transverse aorta constriction mice fractional shortening is reduced compared to similarly treated wild-type controls

• following transverse aorta constriction mice display adaptive cardiac hypertrophy without ventricular dilation

• cardiomyocyte enlargement following pressure overload is reduced compared to similarly treated wild-type controls

cellular

increased mitochondrial number ( J:311513 )

• electron microscopy indicates increased mitochondria numbers in hearts

homeostasis/metabolism

decreased response of heart to induced stress ( J:311513 )

• following transverse aorta constriction mice fractional shortening is reduced compared to similarly treated wild-type controls

• following transverse aorta constriction mice display adaptive cardiac hypertrophy without ventricular dilation

• cardiomyocyte enlargement following pressure overload is reduced compared to similarly treated wild-type controls