Phenotypes associated with this allele

• Allele Symbol: Klhl22^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6782847
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl22^em1Cya/Klhl22^em1Cya	C57BL/6N-Klhl22^em1Cya/Cya	MGI:6782851

Genotype
MGI:6782851

hm1

• Allelic Composition: Klhl22^em1Cya/Klhl22^em1Cya
• Genetic Background: C57BL/6N-Klhl22^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:297538 )

• in a mouse model of injected subcutaneous melanoma, mice exhibit reduced survival compared with wild-type mice

neoplasm

abnormal tumor pathology ( J:297538 )

• in mouse a model of injected subcutaneous melanoma, mice exhibit faster tumor progression within decreased CD4+ and CD8+ T cells producing IFNgamma, TNF, and granzyme B and reduced survival compared with wild-type mice

increased tumor growth/size ( J:297538 )

• in a mouse model of injected subcutaneous melanoma

immune system

decreased interferon-gamma secretion ( J:297538 )

• from CD4+ and CD8 + T cells in a mouse model of injected subcutaneous melanoma

decreased tumor necrosis factor secretion ( J:297538 )

• from CD4+ and CD8 + T cells in a mouse model of injected subcutaneous melanoma