Phenotypes associated with this allele

• Allele Symbol: U2af1^tm1Mohi
• Allele Name: targeted mutation 1, M Golam Mohi
• Allele ID: MGI:6783443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Mx1-cre)1Cgn/0 U2af1^tm1Mohi/U2af1^tm1Mohi	involves: C57BL/6J * CBA/J	MGI:6783985

Genotype
MGI:6783985

cn1

• Allelic Composition: Tg(Mx1-cre)1Cgn/0; U2af1^tm1Mohi/U2af1^tm1Mohi
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:308564 )

• 10 to 14 days after pIpC treatment

hematopoietic system

anemia ( J:308564 )

• in pIpC-treated mice

abnormal bone marrow cell morphology/development ( J:308564 )

• aplasia in pIpC-treated mice

decreased common myeloid progenitor cell number ( J:308564 )

• reduced frequencies and total number in the bone marrow of pIpC-treated mice

decreased bone marrow cell number ( J:308564 )

• in pIpC-treated mice

decreased erythroid progenitor cell number ( J:308564 )

• reduced frequencies and total number in the bone marrow of pIpC-treated mice

decreased megakaryocyte progenitor cell number ( J:308564 )

• reduced frequencies and total number in the bone marrow of pIpC-treated mice

decreased erythrocyte cell number ( J:308564 )

• in pIpC-treated mice

decreased hemoglobin content ( J:308564 )

• in pIpC-treated mice

thrombocytopenia ( J:308564 )

• in pIpC-treated mice

decreased leukocyte cell number ( J:308564 )

• in pIpC-treated mice

decreased neutrophil cell number ( J:308564 )

• in pIpC-treated mice

decreased hematopoietic stem cell number ( J:308564 )

• decreased frequency and absolute numbers of LSK and long-term hematopoietic stem cells, short-term hematopoietic stem cells, and multipotent progenitors in the bone marrow of pIpC-treated mice

pancytopenia ( J:308564 )

• in pIpC-treated mice

abnormal hematopoietic stem cell physiology ( J:308564 )

• impaired repopulation capacity of hematopoietic stem cells with increased cell death and DNA damage in pIpC-treated mice

bone marrow failure ( J:308564 )

• cell autonomous, primary and in bone marrow transplantation experiments, in pIpC-treated mice

immune system

decreased leukocyte cell number ( J:308564 )

• in pIpC-treated mice

decreased neutrophil cell number ( J:308564 )

• in pIpC-treated mice

bone marrow failure ( J:308564 )

• cell autonomous, primary and in bone marrow transplantation experiments, in pIpC-treated mice