Phenotypes associated with this allele

• Allele Symbol: Ano3^tm1.1Lyj
• Allele Name: targeted mutation 1.1, Lily Yeh Jan
• Allele ID: MGI:6790221
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ano3^tm1.1Lyj/Ano3^tm1.1Lyj Tg(Nes-cre)1Kln/0	involves: 129X1/SvJ * C57BL/6	MGI:6790222
cn2	Ano3^tm1.1Lyj/Ano3^tm1.1Lyj Ptgds^tm1.1(cre)Gvn/Ptgds^+	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:6790233

Genotype
MGI:6790222

cn1

• Allelic Composition: Ano3^tm1.1Lyj/Ano3^tm1.1Lyj; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

environmentally induced seizures ( J:310618 )

• mice exhibit increased susceptibility to hyperthermia-induced seizure, with mice reaching phase 4 (tonic convulsions with loss of consciousness) seizures at lower core temperature than wild-type mice and heat exposure causing their core temperature to increase more rapidly

• however, merely raising the ambient temperature to 37 degrees Celsius is not sufficient to induce seizures

homeostasis/metabolism

abnormal body temperature homeostasis ( J:310618 )

• P11 mice exhibit lower core temperature at ambient temperature of 22 or 30 degrees C, but core temperature is comparable to wild-type controls when the ambient temperature is held at 37 degrees C and during the following recovery period at 22 degrees C, indicating that pups experience a more rapid increase of core temperature than wild-type littermates when the ambient temperature is raised from 30 degrees C to 37 degrees C

nervous system

environmentally induced seizures ( J:310618 )

• mice exhibit increased susceptibility to hyperthermia-induced seizure, with mice reaching phase 4 (tonic convulsions with loss of consciousness) seizures at lower core temperature than wild-type mice and heat exposure causing their core temperature to increase more rapidly

• however, merely raising the ambient temperature to 37 degrees Celsius is not sufficient to induce seizures

Genotype
MGI:6790233

cn2

• Allelic Composition: Ano3^tm1.1Lyj/Ano3^tm1.1Lyj; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

behavior/neurological

environmentally induced seizures ( J:310618 )

• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures

• however, mice show comparable susceptibility to chemoconvulsant-induced seizures

homeostasis/metabolism

abnormal body temperature homeostasis ( J:310618 )

• P11 mice exhibit a more rapid core temperature increase upon heat exposure

• P11 mice exhibit lower core temperature at ambient temperature of 22 or 30 degrees Celsius, but core temperature is comparable to wild-type controls when the ambient temperature is held at 37 degrees C

• the slopes of core temperature change with ambient temperature manipulation differs from controls

nervous system

environmentally induced seizures ( J:310618 )

• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures

• however, mice show comparable susceptibility to chemoconvulsant-induced seizures