About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irgm1em1Myam
endonuclease-mediated mutation 1, Masahiro Yamamoto
MGI:6790261
Summary 2 genotypes


Genotype
MGI:6790422
cx1
Allelic
Composition		 Igtpem1Myam/Igtpem1Myam
Irgm1em1Myam/Irgm1em1Myam
Genetic
Background		 C57BL/6-Irgm1em1Myam Igtpem1Myam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igtpem1Myam mutation (0 available); any Igtp mutation (22 available)
Irgm1em1Myam mutation (0 available); any Irgm1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:308470 )
• bone marrow-derived macrophages, bone marrow-derived dendritic cells, and mouse embryonic fibroblast exhibit impaired IFN-gamma-induced reduction of T. gondii numbers compared with wild-type cells




Genotype
MGI:6790418
cx2
Allelic
Composition		 Igtpem1Myam/Igtpem1Myam
Irgm1em1Myam/Irgm1em1Myam
Irgm2em2Myam/Irgm2em2Myam
Genetic
Background		 C57BL/6-Irgm1em1Myam Igtpem1Myam Irgm2em2Myam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igtpem1Myam mutation (0 available); any Igtp mutation (22 available)
Irgm1em1Myam mutation (0 available); any Irgm1 mutation (26 available)
Irgm2em2Myam mutation (0 available); any Irgm2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:308470 )
• bone marrow-derived macrophages, bone marrow-derived dendritic cells, and mouse embryonic fibroblast exhibit impaired IFN-gamma-induced reduction of T. gondii numbers compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory