About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ercc6l2em1Mengf
endonuclease-mediated mutation 1, Feilong Meng
MGI:6791389
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ercc6l2em1Mengf/Ercc6l2em1Mengf Not Specified MGI:6792082
cx2
 		Ercc6l2em1Mengf/Ercc6l2em1Mengf
Nhej1em1Mengf/Nhej1em1Mengf 		Not Specified MGI:6792083


Genotype
MGI:6792082
hm1
Allelic
Composition		 Ercc6l2em1Mengf/Ercc6l2em1Mengf
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6l2em1Mengf mutation (0 available); any Ercc6l2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:311900 )
N
• normal naive splenic B cell numbers and proliferation
• normal activation-induced cytidine deaminase (AID)-induced somatic hypermutation (SHM) in germinal centers of immunized mice
• normal distribution of pro-B (CD43+ B220+ IgM-), pre-B (CD43- B220+ IgM-), immature B (IgM+ B220-low) and recirculating B (IgM+ B220-hi) cells in bone marrow
• normal distribution of CD4- CD8-, CD4+ CD8+, CD4+ CD8- and CD4- CD8+ T cells in thymus
abnormal class switch recombination ( J:311900 )
• reduced ~50% in splenic B cells after stimulation with LPS or LPS+IL4
decreased T cell number ( J:311900 )
• ~50% reduction in thymus

hematopoietic system
abnormal class switch recombination ( J:311900 )
• reduced ~50% in splenic B cells after stimulation with LPS or LPS+IL4
decreased T cell number ( J:311900 )
• ~50% reduction in thymus

mortality/aging
mortality/aging ( J:311900 )
N
• viable




Genotype
MGI:6792083
cx2
Allelic
Composition		 Ercc6l2em1Mengf/Ercc6l2em1Mengf
Nhej1em1Mengf/Nhej1em1Mengf
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6l2em1Mengf mutation (0 available); any Ercc6l2 mutation (38 available)
Nhej1em1Mengf mutation (0 available); any Nhej1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory