Phenotypes associated with this allele

• Allele Symbol: Exph5^tm1Tiz
• Allele Name: targeted mutation 1, Tetsuro Izumi
• Allele ID: MGI:6802112
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exph5^tm1Tiz/Exph5^tm1Tiz	B6NJcl.Cg-Exph5^tm1Tiz/Tiz	MGI:6810738
cx2	Exph5^tm1Tiz/Exph5^tm1Tiz Il33^tm1Snak/Il33^tm1Snak	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:6810739

Genotype
MGI:6810738

hm1

• Allelic Composition: Exph5^tm1Tiz/Exph5^tm1Tiz
• Genetic Background: B6NJcl.Cg-Exph5^tm1Tiz/Tiz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 physiology ( J:313415 )

• enhanced IL-33 responsiveness in IL5/IL13-producing pathogenic Th2 cells

• increased intracellular reactive oxygen species after stimulation with PMA/ionomycin or TCR stimulation

increased susceptibility to type I hypersensitivity reaction ( J:313415 )

• mice sensitized with ovalbumin/alum-sensitized and restimulated exhibit increased IL5, IL13, eosinophil infiltration, and mucus production in the lungs compared with wild-type mice

abnormal interleukin secretion ( J:313415 )

• following injection of external, harmful Alternaria extract, mice exhibit increased IL33 and lactate dehydrogenase secretion into alveolar spaces compared with wild-type mice

• after the third ovalbumin aerosol challenge, mice exhibit increased IL33 secretion into the alveolar spaces compared with wild-type mice

• however, IL33 secretion from bone marrow cells is normal

increased interleukin-13 secretion ( J:313415 )

• in lung homogenate of ovalbumin/alum-sensitized mice restimulated with ovalbumin

increased interleukin-5 secretion ( J:313415 )

• from spleen cells and thoracic lymph nodes isolated from ovalbumin/alum-sensitized mice restimulated with ovalbumin

• in lung homogenate of ovalbumin/alum-sensitized mice restimulated with ovalbumin

respiratory system

increased airway responsiveness ( J:313415 )

• in mice sensitized with ovalbumin/alum-sensitized and restimulated

homeostasis/metabolism

increased lactate dehydrogenase level ( J:313415 )

• following injection of external, harmful Alternaria extract, mice exhibit increased IL33 and lactate dehydrogenase secretion into alveolar spaces compared with wild-type mice

cellular

oxidative stress ( J:313415 )

• increased intracellular reactive oxygen species after stimulation with PMA/ionomycin or TCR stimulation

hematopoietic system

abnormal T-helper 2 physiology ( J:313415 )

• enhanced IL-33 responsiveness in IL5/IL13-producing pathogenic Th2 cells

• increased intracellular reactive oxygen species after stimulation with PMA/ionomycin or TCR stimulation

Genotype
MGI:6810739

cx2

• Allelic Composition: Exph5^tm1Tiz/Exph5^tm1Tiz; Il33^tm1Snak/Il33^tm1Snak
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

respiratory system

increased airway responsiveness ( J:313415 )

• in mice sensitized with ovalbumin/alum-sensitized and restimulated or exposed to dust mites