Phenotypes associated with this allele

• Allele Symbol: Laptm4b^em1Huty
• Allele Name: endonuclease-mediated mutation 1, Huang-Tian Yang
• Allele ID: MGI:6802143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Laptm4b^em1Huty/Laptm4b^em1Huty	C57BL/6-Laptm4b^em1Huty	MGI:6802149

Genotype
MGI:6802149

hm1

• Allelic Composition: Laptm4b^em1Huty/Laptm4b^em1Huty
• Genetic Background: C57BL/6-Laptm4b^em1Huty

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:310542 )

N • normal heart size, weight and function and cardiomyocyte and left ventricle size

increased myocardial infarct size ( J:310542 )

♂ • in left ventricle after induced cardiac ischemia/reperfusion

cellular

abnormal lysosome morphology ( J:310542 )

♂ • reduced lysosome numbers in heart after induced cardiac ischemia/reperfusion

impaired autophagy ( J:310542 )

♂ • impaired autophagic flux (autophagosome accumulation) in heart; further increase after induced cardiac ischemia/reperfusion

growth/size/body

growth/size/body region phenotype ( J:310542 )

N • normal appearance and organ weights (lungs, kidneys, spleens, and livers)

homeostasis/metabolism

increased myocardial infarct size ( J:310542 )

♂ • in left ventricle after induced cardiac ischemia/reperfusion

impaired autophagy ( J:310542 )

♂ • impaired autophagic flux (autophagosome accumulation) in heart; further increase after induced cardiac ischemia/reperfusion

mortality/aging

mortality/aging ( J:310542 )

N • viable