Analysis Tools
behavior/neurological
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• mice bury a higher number of marbles in the marble-burying test, indicating higher anxiety
• however, mice do not show differences in the open field test, novel object recognition, Y-maze test, three-chamber social interaction test, home cage activity test, tail suspension test, forced swim test, administration of MK-801-induced locomotor hyperactivity or sucrose preference test
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nervous system
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• mice exhibit a decrease in percentage of mature dendritic spines (stubby + mushroom + branched) and an increased percentage immature spines (filipodia + thin)
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• dendritic spine density is lower
• however, mice are healthy without any visible abnormalities in growth or morphology and show normal blood biochemical profiles
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• mice exhibit reduced prepulse inhibition at prepulse levels of 70, 78, and 82
• however, average startle response is not different from controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:313946 | |
