All Phenotypes Rprd1b<tm1Tshu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rprd1b^tm1Tshu
targeted mutation 1, Tsinghua University
MGI:6818638

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Tg(Vil1-cre)20Syr/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:6822318
cn2	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Tg(Vil1-cre)20Syr/0	involves: C57BL/6 * DBA/2	MGI:6822317

Allelic Composition	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)
Rprd1b^tm1Tshu mutation (0 available); any Rprd1b mutation (16 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system development ( J:300857 )

• decreased Lgr5-GFP+ cells pre and post tamoxifen treatment

• tamoxifen-treated cultured intestinal crypt organoids exhibit fewer outgrowths and fail to reform after disaggregation unlike control cultures

Allelic Composition	Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Tg(Vil1-cre)20Syr/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rprd1b^tm1Tshu mutation (0 available); any Rprd1b mutation (16 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:300857 )

• all DSS treated mice unlike similarly treated control mice

prenatal lethality, incomplete penetrance ( J:300857 )

• fewer than expected mice are born

digestive/alimentary system

digestive/alimentary phenotype ( J:300857 )

N	• mice exhibit normal villus number and structure in the small intestine

abnormal small intestine goblet cell morphology ( J:300857 )

• reduced number

abnormal digestive system development ( J:300857 )

• impaired proliferation and differentiation of Lgr5+ stem cells

abnormal large intestine crypts of Lieberkuhn morphology ( J:300857 )

• enlarged and thickened

abnormal large intestine goblet cell morphology ( J:300857 )

• reduced number

decreased Paneth cell number ( J:300857 )

• fewer lysozyme positive Paneth cells

impaired intestine regeneration ( J:300857 )

• failure to regenerated colon crypts after X-ray damage

increased susceptibility to colitis induced morbidity/mortality ( J:300857 )

• all DSS treated mice unlike similarly treated control mice

growth/size/body

decreased body weight ( J:300857 )

• in surviving mice

homeostasis/metabolism

impaired wound healing ( J:300857 )

• failure to regenerated colon crypts after X-ray damage

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:300857 )

• all DSS treated mice unlike similarly treated control mice

cellular

abnormal large intestine goblet cell morphology ( J:300857 )

• reduced number

abnormal small intestine goblet cell morphology ( J:300857 )

• reduced number

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:300857 )

• enlarged and thickened

abnormal large intestine goblet cell morphology ( J:300857 )

• reduced number

decreased Paneth cell number ( J:300857 )

• fewer lysozyme positive Paneth cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24