Phenotypes associated with this allele

• Allele Symbol: Garin1b^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6825731
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Garin1b^em1Osb/Garin1b^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6827135

Genotype
MGI:6827135

hm1

• Allelic Composition: Garin1b^em1Osb/Garin1b^em1Osb
• Genetic Background: involves: C57BL/6NJcl * DBA/2NJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm head morphology ( J:314135 )

• hook-like structures at the apical sperm head

abnormal acrosome morphology ( J:314135 )

• over the whole sperm head, swollen

• however, mitochondria morphology is normal

decreased activated sperm motility ( J:314135 )

• slightly decreased average path velocity, straight-line velocity, and curvilinear velocity after incubation in capacitating medium compared with wild-type sperm from mice with a mixed background

• however, sperm motility is comparable to published motility values of C57BL/6 wild-type mice

male infertility ( J:314135 )

• however, infertility is rescued by transgene expression of the wild-type sequence

impaired acrosome reaction ( J:314135 )

impaired sperm penetration of zona pellucida ( J:314135 )

• sperm are unable to fertilize cumulus-intact and cumulus-free oocytes and exhibit reduced fusion to zona pellucida-free oocytes

cellular

abnormal sperm head morphology ( J:314135 )

• hook-like structures at the apical sperm head

abnormal acrosome morphology ( J:314135 )

• over the whole sperm head, swollen

• however, mitochondria morphology is normal

decreased activated sperm motility ( J:314135 )

• slightly decreased average path velocity, straight-line velocity, and curvilinear velocity after incubation in capacitating medium compared with wild-type sperm from mice with a mixed background

• however, sperm motility is comparable to published motility values of C57BL/6 wild-type mice