About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Garin1aem1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6825733
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Garin1aem1Osb/Garin1aem1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6827134


Genotype
MGI:6827134
hm1
Allelic
Composition		 Garin1aem1Osb/Garin1aem1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Garin1aem1Osb mutation (0 available); any Garin1a mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:314135 )
• mild hook-like structures at the apical sperm head
abnormal acrosome morphology ( J:314135 )
• slightly expanded crescent shape
• however, mitochondria morphology is normal
impaired fertilization ( J:314135 )
• decreased fertilization of cumulus-intact and cumulus-free oocytes
• however, fertilization of zona pellucida-free oocytes is normal

cellular
abnormal sperm head morphology ( J:314135 )
• mild hook-like structures at the apical sperm head
abnormal acrosome morphology ( J:314135 )
• slightly expanded crescent shape
• however, mitochondria morphology is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory