Phenotypes associated with this allele

• Allele Symbol: Rab29^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6825753
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab29^tm1b(EUCOMM)Wtsi/Rab29^tm1b(EUCOMM)Wtsi	involves: BALB/cJ * C57BL/6J * C57BL/6N	MGI:7662824

Genotype
MGI:7662824

hm1

• Allelic Composition: Rab29^{tm1b(EUCOMM)Wtsi}/Rab29^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

accumulation of giant lysosomes in kidney/renal tubule cells ( J:314451 )

• late endosome/lysosomes are increased in size in the kidneys

abnormal vesicle-mediated transport ( J:314451 )

• mice show an accumulation of precursor and mature cathepsin D in the kidney, indicating trafficking defects and mis-sorting of lysosomal enzymes

abnormal Golgi vesicle transport ( J:314451 )

• mice show an increase in IGF2R (CI-M6PR), indicating less efficient cycling of CI-M6PR at the trans-Golgi network

renal/urinary system

accumulation of giant lysosomes in kidney/renal tubule cells ( J:314451 )

• late endosome/lysosomes are increased in size in the kidneys