Phenotypes associated with this allele

• Allele Symbol: Npnt^em1Zhwe
• Allele Name: endonuclease-mediated mutation 1, Weishe Zhang
• Allele ID: MGI:6825765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npnt^em1Zhwe/Npnt^em1Zhwe	C57BL/6-Npnt^em1Zhwe	MGI:6825769

Genotype
MGI:6825769

hm1

• Allelic Composition: Npnt^em1Zhwe/Npnt^em1Zhwe
• Genetic Background: C57BL/6-Npnt^em1Zhwe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:314482 )

• mice die the day after birth

• however, mice are born alive with normal size, body weight, and appearance

renal/urinary system

abnormal kidney development ( J:314482 )

• mice show developmental arrest in the nephron in primordial kidneys

absent kidney ( J:314482 )

• 14 of 15 pups have no kidneys on either side; the remaining mouse has two primordial kidneys that are smaller

• however, mice show normal development of the bladder, adrenal glands, and internal genitalia

absent ureter ( J:314482 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bilateral renal aplasia		DOID:0080200		J:314482