Phenotypes associated with this allele

• Allele Symbol: Slc16a13^em1Tac
• Allele Name: endonuclease-mediated mutation 1, Taconic
• Allele ID: MGI:6825806
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc16a13^em1Tac/Slc16a13^em1Tac	C57BL/6N-Slc16a13^em1Tac	MGI:6827174

Genotype
MGI:6827174

hm1

• Allelic Composition: Slc16a13^em1Tac/Slc16a13^em1Tac
• Genetic Background: C57BL/6N-Slc16a13^em1Tac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:309785 )

N • normal white adipose tissue morphology

decreased body fat mass ( J:309785 )

• 20% decrease when fed normal chow (NCD)

• normal when fed high-fat diet (HFD)

liver/biliary system

liver/biliary system phenotype ( J:309785 )

N • normal liver morphology

decreased susceptibility to diet-induced hepatic steatosis ( J:309785 )

• when fed high-fat diet (HFD)

• reduced hepatic triglyceride levels when fed high-fat diet (HFD)

growth/size/body

growth/size/body region phenotype ( J:309785 )

N • normal body weight when fed normal chow (NCD) or high-fat diet (HFD)

decreased body fat mass ( J:309785 )

• 20% decrease when fed normal chow (NCD)

• normal when fed high-fat diet (HFD)

embryo

embryo phenotype ( J:309785 )

N • mice born at normal Mendelian ratios

cellular

abnormal aerobic respiration ( J:309785 )

♀ • increased hepatocyte oxygen consumption rate (OCR) and 25% increase in maximal respiration in vitro when fed normal chow (NCD)

♀ • increased oxygen flux per mass in liver tissue in vitro when fed high-fat diet (HFD)

abnormal mitochondrial ATP synthesis coupled electron transport ( J:309785 )

• increased efficiency in generation of ATP from fatty acids (increased respiratory control ratio, decreased LEAK control ratio) in liver tissue in vitro when fed high-fat diet (HFD)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:309785 )

N • normal energy expenditure, plasma insulin level after glucose administration and respiratory exchange rate (RER) when fed normal chow (NCD) or high-fat diet (HFD)

N • normal liver glycogen storage when fed high-fat diet (HFD)

N • normal hepatic ceramide and plasma non-esterified fatty acid levels when fed high-fat diet (HFD)

N • normal hepatic de novo lipogenesis when fed high-fat diet (HFD)

improved glucose tolerance ( J:309785 )

• reduced blood glucose level after glucose administration when fed high-fat diet (HFD)

• normal glucose tolerance level after glucose administration when fed normal chow (NCD)

increased insulin sensitivity ( J:309785 )

• improved insulin-mediated suppression of endogenous hepatic glucose production when fed high-fat diet (HFD)

• normal peripheral insulin sensitivity when fed high-fat diet (HFD)

behavior/neurological

behavior/neurological phenotype ( J:309785 )

N • normal locomotor activity, energy expenditure and food intake when fed normal chow (NCD)

mortality/aging

mortality/aging ( J:309785 )

N • viable

muscle

muscle phenotype ( J:309785 )

N • normal skeletal muscle morphology

nervous system

nervous system phenotype ( J:309785 )

N • normal brain morphology

renal/urinary system

renal/urinary system phenotype ( J:309785 )

N • normal kidney morph