Phenotypes associated with this allele

• Allele Symbol: Cachd1^tow
• Allele Name: tilt-o-whirl
• Allele ID: MGI:6827187
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cachd1^tow/Cachd1^tow	B6(Cg)-Cachd1^tow/GrsrKjn	MGI:6827190

Genotype
MGI:6827190

hm1

• Allelic Composition: Cachd1^tow/Cachd1^tow
• Genetic Background: B6(Cg)-Cachd1^tow/GrsrKjn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired swimming ( J:314293 )

• homozygotes fail to orient in water

head tilt ( J:314293 )

circling ( J:314293 )

• incomplete penetrance, with overt circling and head tilting found in only approximately 45% of homozygotes

hearing/vestibular/ear

abnormal inner ear morphology ( J:314293 )

abnormal inner ear development ( J:314293 )

abnormal utricle morphology ( J:314293 )

abnormal vestibular saccule morphology ( J:314293 )

decreased otolith number ( J:314293 )

• variable deficiencies of otoconia in both the saccule and utricle

increased or absent threshold for auditory brainstem response ( J:314293 )

• between 5-12 weeks of age the average increase in ABR threshold is 40-50 dB, this is variable and not fully penetrant, but those mice displaying a vestibular phenotype usually have elevated ABR thresholds, and the hearing loss does not progress with age from 1 to 6 months of age