Phenotypes associated with this allele

• Allele Symbol: Ism1^em1.1Kajs
• Allele Name: endonuclease-mediated mutation 1.1, Katrin J Svensson
• Allele ID: MGI:6827291
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ism1^em1.1Kajs/Ism1^em1.1Kajs	involves: C57BL/6J * FVB/N	MGI:6827296

Genotype
MGI:6827296

hm1

• Allelic Composition: Ism1^em1.1Kajs/Ism1^em1.1Kajs
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:309734 )

N • normal primary inguinal cell differentiation into adipocytes in vitro

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:309734 )

N • normal body temperature when fed normal chow

N • normal insulin levels when fed normal chow

impaired glucose tolerance ( J:309734 )

• when fed normal chow

• reduced brown adipose tissue (BAT) glucose uptake when fed normal chow

• reduced skeletal muscle glucose uptake when fed non-alcoholic fatty liver disease diet

• normal inguinal white adipose tissue (iWAT) and liver glucose uptake when fed normal chow, high-fat diet or non-alcoholic fatty liver disease diet

insulin resistance ( J:309734 )

• reduced insulin sensitivity (reduced insulin-induced signaling and glucose uptake) in in vitro differentiated adipocytes

growth/size/body

growth/size/body region phenotype ( J:309734 )

N • normal body weight when fed normal chow

behavior/neurological

behavior/neurological phenotype ( J:309734 )

N • normal food intake when fed normal chow