All Phenotypes Actl7a<em1Fzh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Actl7a^em1Fzh
endonuclease-mediated mutation 1, Feng Zhang
MGI:6827375

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actl7a^em1Fzh/Actl7a^em1Fzh	C57BL/6-Actl7a^em1Fzh	MGI:6827377

Allelic Composition	Actl7a^em1Fzh/Actl7a^em1Fzh
Genetic Background	C57BL/6-Actl7a^em1Fzh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actl7a^em1Fzh mutation (0 available); any Actl7a mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:313844 )

N	• female mice exhibit normal fertility

abnormal acrosome morphology ( J:313844 )

• cap-like structure with increased subacrosomal layer and the post-acrosomal sheath in the perinuclear theca

detached acrosome ( J:313844 )

male infertility ( J:313844 )

• despite normal semen characteristics, testis size, and testis weight

impaired fertilization ( J:313844 )

• sperm are unable to fertilize oocytes by in vitro fertilization and intracytoplasmic sperm injection

• however, artificial oocyte activation following intracytoplasmic sperm injection restores fertilization

cellular

abnormal acrosome morphology ( J:313844 )

• cap-like structure with increased subacrosomal layer and the post-acrosomal sheath in the perinuclear theca

detached acrosome ( J:313844 )

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