About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Actl7aem1Fzh
endonuclease-mediated mutation 1, Feng Zhang
MGI:6827375
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Actl7aem1Fzh/Actl7aem1Fzh C57BL/6-Actl7aem1Fzh MGI:6827377


Genotype
MGI:6827377
hm1
Allelic
Composition		 Actl7aem1Fzh/Actl7aem1Fzh
Genetic
Background		 C57BL/6-Actl7aem1Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actl7aem1Fzh mutation (0 available); any Actl7a mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:313844 )
N
• female mice exhibit normal fertility
abnormal acrosome morphology ( J:313844 )
• cap-like structure with increased subacrosomal layer and the post-acrosomal sheath in the perinuclear theca
male infertility ( J:313844 )
• despite normal semen characteristics, testis size, and testis weight
impaired fertilization ( J:313844 )
• sperm are unable to fertilize oocytes by in vitro fertilization and intracytoplasmic sperm injection
• however, artificial oocyte activation following intracytoplasmic sperm injection restores fertilization

cellular
abnormal acrosome morphology ( J:313844 )
• cap-like structure with increased subacrosomal layer and the post-acrosomal sheath in the perinuclear theca




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory