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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fanciem2Szh
endonuclease-mediated mutation 2, Shidou Zhao
MGI:6827419
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fanciem2Szh/Fanciem2Szh Not Specified MGI:6827421


Genotype
MGI:6827421
hm1
Allelic
Composition		 Fanciem2Szh/Fanciem2Szh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanciem2Szh mutation (0 available); any Fanci mutation (200 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased male germ cell number ( J:312543 )
• at 8 weeks and more severe at 12 months
increased male germ cell apoptosis ( J:312543 )
• despite normal meiotic progression and meiotic recombination
abnormal DNA methylation during gametogenesis ( J:312543 )
• increased accumulation of H3K9me3 on sex chromosomes
seminiferous tubule degeneration ( J:312543 )
• with massive cell loss

endocrine/exocrine glands
seminiferous tubule degeneration ( J:312543 )
• with massive cell loss

cellular
decreased male germ cell number ( J:312543 )
• at 8 weeks and more severe at 12 months
increased male germ cell apoptosis ( J:312543 )
• despite normal meiotic progression and meiotic recombination
abnormal DNA methylation during gametogenesis ( J:312543 )
• increased accumulation of H3K9me3 on sex chromosomes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory