About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Paxbp1tm1.1Nju
targeted mutation 1.1, Model Animal Research Center of Nanjing University
MGI:6827438
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju 		involves: 129S1/Sv * 129X1/SvJ MGI:6827450
cn2
 		Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Pax7tm1(cre/ERT2)Gaka/Pax7tm1(cre/ERT2)Gaka
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr MGI:6827448


Genotype
MGI:6827450
cn1
Allelic
Composition		 Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)
Paxbp1tm1.1Nju mutation (0 available); any Paxbp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6827448
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Pax7tm1(cre/ERT2)Gaka/Pax7tm1(cre/ERT2)Gaka
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (994 available)
Pax7tm1(cre/ERT2)Gaka mutation (1 available); any Pax7 mutation (38 available)
Paxbp1tm1.1Nju mutation (0 available); any Paxbp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial morphology ( J:304562 )
• fragmented mitochondria, largely restricted to perinuclear region, lacking interconnecting tubular network in activated muscle stem cells
abnormal respiratory electron transport chain ( J:304562 )
• defective cellular respiration and glycolysis
abnormal mitochondrial ATP synthesis coupled electron transport ( J:304562 )
• defective cellular respiration and glycolysis
decreased mitochondrial fission ( J:304562 )
• defective mitochondrial biogenesis in activated muscle stem cells
abnormal oxidative phosphorylation ( J:304562 )
• defective cellular respiration and glycolysis

muscle
impaired skeletal muscle regeneration ( J:304562 )
• virtual absence of regenerating myofibers 5 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles and no muscle regeneration after 14 nor 30 days
• adipocyte infiltration 30 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory