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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ins2-Mirc13)E4Biat
transgene insertion E4, Biomodels Austria
MGI:6828985
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Trp53tm1Tyj/Trp53+
Tg(Ins2-Mirc13)E4Biat/0 		involves: 129S2/SvPas * C57BL/6N MGI:6829612
cx2
 		Badtm1Sjk/Badtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0 		involves: 129X1/SvJ * C57BL/6N MGI:6829608
cx3
 		Baxtm1Sjk/Baxtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0 		involves: 129X1/SvJ * C57BL/6N MGI:6829609
cx4
 		Tg(Ins2-Mirc13)E4Biat/0
Tg(RIP1-Tag)2Dh/0 		involves: C57BL/6J * C57BL/6N * DBA/2J MGI:6829611
tg5
 		Tg(Ins2-Mirc13)E4Biat/0 C57BL/6N-Tg(Ins2-Mirc13)E4Biat MGI:6829614


Genotype
MGI:6829612
cx1
Allelic
Composition		 Trp53tm1Tyj/Trp53+
Tg(Ins2-Mirc13)E4Biat/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Mirc13)E4Biat mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:314874 )
N
• mice exhibit normal glucose serum levels unlike mice expressing the transgene alone




Genotype
MGI:6829608
cx2
Allelic
Composition		 Badtm1Sjk/Badtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Badtm1Sjk mutation (0 available); any Bad mutation (25 available)
Tg(Ins2-Mirc13)E4Biat mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
hyperglycemia ( J:314874 )
• after a 4 h fast, mice exhibit increased blood glucose levels as in mice with the transgene alone




Genotype
MGI:6829609
cx3
Allelic
Composition		 Baxtm1Sjk/Baxtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Ins2-Mirc13)E4Biat mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:314874 )
N
• mice exhibit normal beta cell mass unlike mice expressing the transgene alone

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:314874 )
N
• mice exhibit normal glucose serum levels after a 4 h fast unlike mice expressing the transgene alone




Genotype
MGI:6829611
cx4
Allelic
Composition		 Tg(Ins2-Mirc13)E4Biat/0
Tg(RIP1-Tag)2Dh/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Mirc13)E4Biat mutation (0 available)
Tg(RIP1-Tag)2Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:314874 )
N
• mice exhibit normal glucose serum levels after a 4 h fast unlike mice expressing the Mirc13 transgene alone

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:314874 )
N
• mice exhibit normal beta cell mass unlike mice expressing the Mirc13 transgene alone




Genotype
MGI:6829614
tg5
Allelic
Composition		 Tg(Ins2-Mirc13)E4Biat/0
Genetic
Background		 C57BL/6N-Tg(Ins2-Mirc13)E4Biat
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:314874 )
• at 6 and 17 weeks of age
hyperglycemia ( J:314874 )
• severe

endocrine/exocrine glands
decreased pancreatic beta cell mass ( J:314874 )
• at 6 and 17 weeks of age
• however, alpha cell mass is normal
decreased insulin secretion ( J:314874 )
• at 6 and 17 weeks of age

growth/size/body
decreased body fat mass ( J:314874 )

adipose tissue

cellular




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory