behavior/neurological
• mice show decreased muscle strength by about 12% and about 11% in males and females, respectively, as measured by grip strength
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muscle
• thin filaments are on average about 8.4% shorter in soleus muscle
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• 50-week-old mice exhibit an age-dependent, 8-fold increase in centrally located nuclei within muscle fibers, indicating ongoing muscle repair after injury
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• isolated intact soleus muscles generate about 11% lower absolute maximal force compared to wild-type muscles
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• mice show decreased muscle strength by about 12% and about 11% in males and females, respectively, as measured by grip strength
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cellular
• mice show absence of cytoplasmic actin processing across all tissues resulting in a cytoskeleton composed of immature actin molecules
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mortality/aging
N |
• mice are viable and born at expected ratios and show no obvious genotype-specific morbidity during the first year of life
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