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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Actmapem1Nki
endonuclease-mediated mutation 1, The Netherlands Cancer Institute
MGI:6831070
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Actmapem1Nki/Actmapem1Nki FVB/N-Actmapem1Nki MGI:7423599


Genotype
MGI:7423599
hm1
Allelic
Composition
Actmapem1Nki/Actmapem1Nki
Genetic
Background
FVB/N-Actmapem1Nki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actmapem1Nki mutation (0 available); any Actmap mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show decreased muscle strength by about 12% and about 11% in males and females, respectively, as measured by grip strength

muscle
• thin filaments are on average about 8.4% shorter in soleus muscle
• 50-week-old mice exhibit an age-dependent, 8-fold increase in centrally located nuclei within muscle fibers, indicating ongoing muscle repair after injury
• isolated intact soleus muscles generate about 11% lower absolute maximal force compared to wild-type muscles
• mice show decreased muscle strength by about 12% and about 11% in males and females, respectively, as measured by grip strength

cellular
• mice show absence of cytoplasmic actin processing across all tissues resulting in a cytoskeleton composed of immature actin molecules

mortality/aging
N
• mice are viable and born at expected ratios and show no obvious genotype-specific morbidity during the first year of life





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory