Phenotypes associated with this allele

• Allele Symbol: Slc4a5^tvrm77
• Allele Name: translational vision research model 77
• Allele ID: MGI:6835638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc4a5^tvrm77/Slc4a5^tvrm77	C57BL/6J-Slc4a5^tvrm77/Pjn	MGI:6886197

Genotype
MGI:6886197

hm1

• Allelic Composition: Slc4a5^tvrm77/Slc4a5^tvrm77
• Genetic Background: C57BL/6J-Slc4a5^tvrm77/Pjn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

retina neovascularization ( J:321062 )

vision/eye

abnormal ocular fundus morphology ( J:321062 )

• subretinal fluid

abnormal retina morphology ( J:321062 )

retina neovascularization ( J:321062 )

abnormal retina pigment epithelium morphology ( J:321062 )

thin retina outer nuclear layer ( J:321062 )

retina degeneration ( J:321062 )

• outer nuclear layer is thinner than normal by 4 months of age

retina detachment ( J:321062 )

retina fold ( J:321062 )

retina spots ( J:321062 )

• the central retina in many homozygotes has hypopigmented patches, small spots and white line lesions, and more commonly a white halo or haziness toward the periphery of the retina, which are retinal folds and detachments

abnormal electroretinogram waveform feature ( J:321062 )

decreased FO-wave amplitude ( J:321062 )

decreased a-wave amplitude ( J:321062 )

• at 12 months of age, but normal at 2 months of age

decreased b-wave amplitude ( J:321062 )

• at 12 months of age, but normal at 2 months of age

increased c-wave amplitude ( J:321062 )

• as early as 2 months of age, the earliest time assessed, and the off-response and fast oscillation are decreased compared to normal, indicating a loss of basal membrane function

pigmentation

abnormal retina pigment epithelium morphology ( J:321062 )