Phenotypes associated with this allele

• Allele Symbol: Cct8^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6836735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cct8^em1(IMPC)J/Cct8^em1(IMPC)J	C57BL/6NJ-Cct8^em1(IMPC)J/Mmjax	MGI:7471924

Genotype
MGI:7471924

hm1

• Allelic Composition: Cct8^em1(IMPC)J/Cct8^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Cct8^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Cct8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cct8^em1(IMPC)J/Cct8^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts grown in vitro fail to hatch from the zona pellucida.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• blastocysts are recovered at E3.5 (15% versus expected 25%, n=20); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

failure of embryo implantation ( J:279207 )

• in vitro, embryos fail to hatch and are dead after 3 days in culture, never forming outgrowths