Phenotypes associated with this allele

• Allele Symbol: Banf1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6836771
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Banf1^em1(IMPC)J/Banf1^em1(IMPC)J	C57BL/6NJ-Banf1^em1(IMPC)J/Mmjax	MGI:7551050
ht2	Banf1^em1(IMPC)J/Banf1^+	C57BL/6NJ-Banf1^em1(IMPC)J/Mmjax	MGI:7471888

Genotype
MGI:7551050

hm1

• Allelic Composition: Banf1^em1(IMPC)J/Banf1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Banf1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Banf1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Banf1^em1(IMPC)J/Banf1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro fail to hatch from the zona pellucida.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• blastocysts are recovered at E3.5 (11% versus expected 25%, n=50); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:7471888

ht2

• Allelic Composition: Banf1^em1(IMPC)J/Banf1⁺
• Genetic Background: C57BL/6NJ-Banf1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Banf1

integument

abnormal coat/ hair morphology ( J:211773 )

♂

IMPC - JAX

abnormal coat appearance ( J:211773 )

♂

IMPC - JAX